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Why GLP1 Drugs Are on Alzheimers Researchers Radar GLP1 receptor agonists work by mimicking a naturally occurring gut hormone (glucagonlike peptide1) that helps regulate blood sugar, appetite and insulin signalling

Additionally, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion

The main GLP-1 drug risks include developing gallstones, pancreatitis, or more severe gastrointestinal problems, such as a bowel obstruction or gastroparesis (in which the muscles in the stomach dont move food properly for digestion), although these are rare

These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig

Its a bit like having a direct measure of how fast your brain is ageing